diff --git a/Misc/NEWS.d/next/Library/2026-07-21-20-34-05.gh-issue-154389.DlTiii.rst b/Misc/NEWS.d/next/Library/2026-07-21-20-34-05.gh-issue-154389.DlTiii.rst
new file mode 100644
index 00000000000000..eb2e2edc2d720e
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2026-07-21-20-34-05.gh-issue-154389.DlTiii.rst
@@ -0,0 +1,3 @@
+Fix :func:`uuid.uuid1` on OpenBSD:
+it returned a version 4 UUID,
+because ``uuid_create()`` generates random UUIDs on this platform.
diff --git a/configure b/configure
index 717a2079124129..7be3c3ec7c94d9 100755
--- a/configure
+++ b/configure
@@ -14668,9 +14668,10 @@ then :
 
 fi
 
-# gh-124228: While the libuuid library is available on NetBSD, it supports only UUID version 4.
+# gh-124228: While the libuuid library is available on NetBSD and OpenBSD,
+# it supports only UUID version 4.
 # This restriction inhibits the proper generation of time-based UUIDs.
-if test "$ac_sys_system" = "NetBSD"; then
+if test "$ac_sys_system" = "NetBSD" || test "$ac_sys_system" = "OpenBSD"; then
   have_uuid=missing
   printf "%s\n" "#define HAVE_UUID_H 0" >>confdefs.h
 
diff --git a/configure.ac b/configure.ac
index cac2f931c91aa1..92b0a3c8962559 100644
--- a/configure.ac
+++ b/configure.ac
@@ -3894,9 +3894,10 @@ AS_VAR_IF([ac_cv_have_uuid_generate_time_safe], [yes], [
   AC_DEFINE([HAVE_UUID_GENERATE_TIME_SAFE], [1])
 ])
 
-# gh-124228: While the libuuid library is available on NetBSD, it supports only UUID version 4.
+# gh-124228: While the libuuid library is available on NetBSD and OpenBSD,
+# it supports only UUID version 4.
 # This restriction inhibits the proper generation of time-based UUIDs.
-if test "$ac_sys_system" = "NetBSD"; then
+if test "$ac_sys_system" = "NetBSD" || test "$ac_sys_system" = "OpenBSD"; then
   have_uuid=missing
   AC_DEFINE([HAVE_UUID_H], [0])
 fi